Developmental expression patterns of the signaling adapters FRS-2 and FRS-3 during early embryogenesis

نویسندگان

  • Kathryn McDougall
  • Chris Kubu
  • Joseph M Verdi
  • Susan O Meakin
چکیده

Two fibroblast growth factor (FGF) receptor substrates (FRS2 and FRS3) are involved in downstream signaling from activated FGF receptors and neurotrophin-activated Trk receptors. Despite the importance of signaling from these factors in embryogenesis, FRS2 and FRS3 expression patterns during development are unknown. In this study we characterize the expression of FRS2 and FRS3 from E7 to parturition and in adult murine tissues. Both are first detected in whole E8.5 CD1 mouse embryos. FRS2 is detected as early as E7 in the developing syncytiotrophoblast, later in the neural tube (NT) and in many adult and fetal tissues. FRS3 is more restricted in location than FRS2 (fetal NT, heart, stomach, liver and some adult tissues), and is expressed predominantly in the ventricular layer of the developing NT and brains of murine embryos.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development.

Fibroblast growth factor receptor 1 (Fgfr1) plays pleiotropic roles during embryonic development, but the mechanisms by which this receptor signals in vivo have not previously been elucidated. Biochemical studies have implicated Fgf receptor-specific substrates (Frs2, Frs3) as the principal mediators of Fgfr1 signal transduction to the MAPK and PI3K pathways. To determine the developmental requ...

متن کامل

P-24: Opioid and Progesterone Signaling Is Obligatoryfor Early Human Embryogenesis

Background: The growth factors that drive the division and differentiation of stem cells during early human embryogenesis are unknown. The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may direc...

متن کامل

Fungal Rhinosinusitis: Study of Risk Factors, Outcome and Utility of Nasal Samples in Its Diagnosis

Background and Aim: Fungal rhinosinusitis (FRS) sets in following interactivity of fungi with Sino nasal tract when immune system is subdued. Due to varied clinical presentation of FRS with inconclusive evidence of imaging, mycological evaluation helps to identify and speciate the fungi .FRS can be diagnosed with biopsy tissue and/or deep nasal swabs. This study was undertaken to know risk fact...

متن کامل

P-88: Assessing Expression Changes of Some Wnt Pathway Genes During Goat Early Embryonic Development

Background: The developmental competency of embryos is affected by several factors, including the developmental pathways and their elements. In mammalian species including goat, fertilized oocyte undergoes several divisions to form a structure called blastocyst. These events depend on the successful control of temporal and spatial expression of genes involved in genome activation. One of the cr...

متن کامل

The role of the desert hedgehog signaling pathway during degeneration and regeneration of peripheral nerves

The desert hedgehog (Dhh) signaling pathway is involved in the development of peripheral nerves (PNs). Dhh-null mice show abnormal neuronal development and perineurial barrier function. As it was previously shown that dhh is mainly expressed in developmental nerves and Sonic hedgehog protein (dhh homologous) has therapeutic effects in neuronal survival, we attempted to investigate the possible ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Mechanisms of Development

دوره 103  شماره 

صفحات  -

تاریخ انتشار 2001